For Guardians looking to add a uniquely potent Exotic to their arsenal, the Osteo Striga submachine gun offers an exciting prospect. This weapon is not merely a tool for dispatching foes; it fires sentient, toxic projectiles that track targets and can trigger devastating poison bursts, making it a formidable choice for crowd control. Its craftable nature further enhances its appeal, allowing players to tailor it to their preferences over time. This guide provides a comprehensive walkthrough for acquiring the Osteo Striga pattern, crafting the weapon, obtaining and completing its powerful catalyst, and offers tips to maximize its effectiveness in the field. The journey to mastering Osteo Striga begins with a pivotal adventure and culminates in wielding a truly unique instrument of destruction.

Getting the Osteo Striga Pattern
The path to acquiring the Osteo Striga begins with a significant undertaking: the completion of the entire The Witch Queen story campaign. This narrative journey serves as a gateway, and fortunately, it can be completed on any difficulty setting, allowing Guardians of all skill levels to access the weapon's pattern. The campaign itself is a substantial adventure, as noted by players who found it to be quite lengthy. However, this undertaking is not merely a prerequisite; it also organically introduces players to the weapon crafting system at the heart of Osteo Striga's acquisition and customization.
Once the final mission of The Witch Queen campaign, titled "The Ritual," is concluded, the next step is to claim the weapon pattern. This is done by navigating to the Triumphs screen and accessing the "Patterns and Catalysts" tab. Locating and unlocking the pattern here is the formal step that allows a Guardian to begin the crafting process. Providing these specific instructions is important, as newer players might otherwise be unsure where to find their newly earned blueprint.
Crafting at the Enclave
With the pattern secured, the next destination is the Enclave on Mars, the hub for all weapon crafting activities. Within the Enclave lies the Relic, the specialized forge where Guardians can "Shape" their weapons.
To craft the Osteo Striga for the first time, a specific set of resources is required. Gathering these materials is a key step, and understanding what is needed can streamline the process. Some of these materials, if a Guardian finds themselves short, can be acquired from vendors like Master Rahool or Banshee-44 in the Tower.
Material | Amount | Quick Tip on Getting It |
---|---|---|
Glimmer | 42,500 | Earned from nearly all in-game activities and slain enemies. |
Enhancement Prism | 2 | High-difficulty in-game activities, also purchasable. |
Ascendant Alloy | 1 | Weekly Witch Queen campaign mission, high-difficulty in-game activities, vendor rank-ups, also purchasable. |
Once at the Relic with the necessary components, players should select the "Shape" option, navigate to the Submachine Gun category, and locate Osteo Striga. The initial version of the weapon will come with a fixed set of perks: Polygonal Rifling for the barrel, Steady Rounds for the magazine, and Hand-Laid Stock for the stock. It is important for Guardians to understand that this first iteration is a baseline; the weapon's true potential is unlocked through leveling and subsequent reshaping. After selecting these initial components and the Exotic perk Toxic Overload, the shape is finalized, and the first Osteo Striga is forged.
Leveling Your Weapon
Forging the Osteo Striga is just the beginning. To unlock its full capabilities, the weapon must be leveled up through use. Leveling serves multiple purposes: it grants access to a wider and improved selection of perks for the barrel, magazine, and stock slots; it is essential for unlocking the ability to install the Exotic Catalyst at weapon Level 10; and it provides a minor boost to all of the weapon's stats at Level 20.
The primary method for leveling Osteo Striga, like any craftable weapon, is by defeating enemies and completing activities while the weapon is equipped. If you have enough Glimmer and Enhancement Cores, you can also open your weapon's menu and use the "Increase Weapon Level" option to reach level 10 faster.
For Player versus Environment (PvE) encounters, where Osteo Striga typically shines, certain early perks are highly recommended.
Perk Slot | Perk Name | Why It's Good | Unlocks at Level (Approx.) |
---|---|---|---|
Barrel | Smallbore | Increases Range and Stability. | 9 |
Barrel | Fluted Barrel | Improves Handling and Stability, making it feel snappier. | 5 |
Magazine | Accurized Rounds | Increases Range, allowing poison to reach further. | 7 |
Magazine | Flared Magwell | Increases Reload Speed and Stability. | 6 |
Stock | Short-Action Stock | Improves Handling. | 4 |
Focusing on these early enhancements can make the journey to Level 10 more enjoyable and effective.
Osteo Striga Catalyst
The true transformation of Osteo Striga occurs with its Exotic Catalyst. The ability to craft this catalyst is unlocked once the weapon reaches Level 10. This milestone signifies that the weapon is ready for its most significant upgrade.
Upon reaching Level 10, Guardians must return to the Relic in the Enclave. Here, they can slot in the catalyst, provided they have the necessary crafting materials. The resources for the catalyst are distinct from the initial weapon crafting costs and are generally rarer.
The benefits conferred by the Osteo Striga Catalyst are substantial, elevating the weapon's performance dramatically. Key enhancements include:
- Significantly increased reload speed.
- Poison final blows return ammunition to the magazine. This is a cornerstone of the catalyst's power, often allowing for continuous fire without manual reloads, especially in enemy-dense situations.
- Increased stability.
- The magazine can be overflowed to a considerable degree, with reports of it reaching 80-108 rounds.
These upgrades, particularly the ammo regeneration on poison kills, transform Osteo Striga into an exceptionally efficient tool for clearing large groups of enemies.

Catalyst Farming Locations
If you're looking to complete your Osteo Striga's transformation as soon as possible and outfit it with all desired perks and the catalyst at the Relic, the most straightforward path would be to just farm the required amount of weapon levels by getting kills with this Exotic. Completing activities while concentrating on getting the highest possible amount of kills is the preferred method, but can quickly overwhelm a new player and may not always feel reliable. Moreover, newer players, or as they're often called, kinderguardians, can lack the necessary materials that more experienced players could spend on leveling the weapon. So, kill farming it is!
To expedite this process, the Destiny 2 community has identified several highly efficient locations for farming weapon kills and level progress. Utilizing these spots can significantly reduce the time needed to masterwork the Osteo Striga.
Location | Why It Rocks | Pro-Tip |
---|---|---|
Shuro Chi Checkpoint (Last Wish Raid) | Extremely high density of weak enemies, rally banner access. | Obtain the checkpoint from another player. |
Altars of Sorrow (Moon) | Continuous waves of Hive enemies, public event. | Good for more casual farming while engaging in an activity. |
"A Mysterious Disturbance" (Moon mission) | Infinite spawning Thrall in specific areas. | Locate the thrallway. |
Breakneck Mission (Lightfall Campaign Checkpoint) | Free rally banner, densely packed Vex, easy reset. | Wipe by the Wyvern at the end of the first room to quickly reset. |

Advanced Tips & Synergies
Several strategies and synergies can elevate Osteo Striga's performance even further.
For Warlock players, the combination of Osteo Striga and the Necrotic Grip Exotic gauntlets is exceptionally powerful. The poison damage from Osteo Striga interacts with Necrotic Grip's perk, causing the poison to spread more aggressively upon melee hits and from enemies defeated by the poison. This creates a cascading effect that can decimate large groups of foes. Some observations even suggest that this synergistic poison can trigger melee-related perks and fragments, offering deeper build-crafting potential.
The poison damage from Osteo Striga interacts with Necrotic Grip's perk, causing the poison to spread more aggressively upon melee hits and from enemies defeated by the poison.
Understanding how to work with Osteo Striga's poison is also key. The weapon triggers an area-of-effect poison burst on final blows or multiple precision hits. It's worth noting that a balance adjustment introduced a short cooldown to these poison explosions. This doesn't diminish the weapon's effectiveness but encourages a certain rhythm: engaging a group, allowing the poison to take effect, and then moving to the next. For sustained damage on tougher targets like Champions or bosses, one advanced technique is to apply the poison and then switch to another weapon, allowing the full duration of the poison to deal damage without being prematurely reset by subsequent Osteo Striga hits.
Armor mods can further enhance Osteo Striga's capabilities:
- Kinetic Siphon (Helmet Mod): Precision final blows with Osteo Striga (a Kinetic weapon) will generate Orbs of Power. Orbs benefit the entire fireteam by providing Super energy and enabling Armor Charge pickups.
- SMG-Enhancing Mods (Arms, Chest, Legs): Mods such as SMG Targeting, Dexterity, Loader, Reserves, and Unflinching improve the weapon's handling, reload speed, ammunition capacity, and stability under fire.
- Kinetic Weapon Surge (Legs Mod): When a Guardian has stacks of Armor Charge (typically gained by picking up Orbs of Power), Kinetic Weapon Surge mods provide a direct damage bonus to Osteo Striga. This system is the modern equivalent of older damage perks like High Energy Fire.
With the knowledge of how to acquire the pattern, craft the weapon and its potent catalyst, and optimize its use through perks and mods, Guardians are well-equipped to unleash the full power of Osteo Striga. This Exotic SMG offers a unique and satisfying playstyle, centered around its tracking, toxic projectiles, and the ensuing poison devastation. The journey from campaign completion to a fully masterworked Osteo Striga is a rewarding one, culminating in a weapon that excels at clearing waves of enemies and synergizes powerfully with specific Exotic armors and builds. The swarm awaits its master.